Gastroenterology

Gastrointestinal (GI) diseases can be complex, debilitating, and life-changing. For more than 25 years, Takeda and our collaboration partners have focused on improving the lives of patients through the delivery of innovative medicines and dedicated patient disease support programs. Takeda is leading in areas of gastroenterology associated with high unmet need, such as inflammatory bowel disease, acid-related diseases and motility disorders. Our R&D organization is investigating new treatments for inflammatory bowel disease, celiac and other luminal gut diseases, motility disorders and liver diseases.

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Disease areas

Inflammatory Bowel Disease
Ulcerative colitis (UC) and Crohn’s disease (CD) are marked by inflammation in the lining of the gastrointestinal tract. UC impacts the large intestine only, which includes the colon and the rectum, while CD can impact any part of the digestive tract, and predominantly affects the ileum. There is no known cause for UC and CD, although many researchers believe that the interaction between genes, the body’s immune system, and environmental factors may play a role.

Chronic Idiopathic Constipation
Chronic Idiopathic Constipation (CIC) is characterized by difficult, infrequent or incomplete passage of stools over a prolonged period and a range of symptoms, which may include abdominal pain and/or bloating. The condition, which affect about 14% of the adult population, has many potential causes. One of the possible underlying problems is an impairment or dysfunction of the gut’s ability to move, by contracting and releasing, naturally. CIC can significantly impact a person’s life and increase in medical care.

Short Bowel Syndrome
Short bowel syndrome (SBS) is a serious and chronic malabsorption disorder. Short bowel syndrome occurs when parts of the intestine are removed surgically and the remaining intestine may not be able to absorb enough nutrients from food and drink. This results in malabsorption. It puts people at risk for: Malnutrition, Electrolyte disturbances, Dehydration, Diarrhea/increased outputs. There are multiple factors that may be used to determine an SBS diagnosis, not just the length of remaining bowel.

Gastroesophageal reflux disease
Gastroesophageal reflux disease, or GERD, occurs when stomach acid used for digestion repeatedly backs up, or refluxes, into the esophagus. GERD is also known as acid reflux disease. Heartburn, often described as pain or burning in the chest, is a common symptom of GERD. Other symptoms include sour taste in the mouth, burning in the throat, and burping. With continued exposure to stomach acid, the esophagus may become irritated and possibly even damaged, a condition known as erosive esophagitis.  



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